Working group: "Computational Biology"

2010, the 07th of December


Title: Conservation dynamics and sequence contexts preferences of methylated cytosines during the cell differentiation process


DNA methylation is an important epigenetic mark that affects cytosine (one of the four bases of DNA), and is essential for normal development and associated with a number of key cell processes (like gene silencing and differentiation). Based on data from two studies published in Genome Research and Nature, we are investigating the conservation dynamics methylated cytosines in human cells, both pluripotent (stem cells) and somatic (differentiated cells). In this talk I will present the (preliminary) unexpected results of this investigation and we will discuss potential interpretations.