Working group: "Computational Biology"
2010, the 07th of December
Nicolas TCHITCHEK
Title: Conservation dynamics and sequence contexts preferences of methylated
cytosines during the cell differentiation process
Abstract:
DNA methylation is an important epigenetic mark that affects cytosine (one
of the four bases of DNA),
and is essential for normal development and associated with a number of key
cell processes (like gene silencing and differentiation).
Based on data from two studies published in Genome Research and Nature, we
are investigating
the conservation dynamics methylated cytosines in human cells, both
pluripotent (stem cells) and somatic (differentiated cells).
In this talk I will present the (preliminary) unexpected results of this
investigation and we will discuss potential interpretations.